Selank Peptide 5mg
Selank is a synthetic derivative of the tetrapeptide tuftsin that contains a proline-glycine-proline sequence at the C-terminus and has anxiolytic and anti-inflammatory activities.1,2,3,4 It increases the amplitude and discharge rate of inhibitory postsynaptic currents of neurons in the rat hippocampal CA1 region when used at a concentration of 1 μM.1 It decreases the level of affective responses and the number of erroneous escape attempts in rats in an acute stress situation, increases orientational-investigative responses of rats in an unfamiliar situation, and reduces the time mice spend immobile in the forced swim test.2 It increases locomotor activity of high-anxiety Balb/c, but not C57Bl/6, mice in the open field test. Selank (0.01 mg/kg) decreases verticalization induced by apomorphine in mice.3 It also decreases expression of the inflammation-related genes Il2rg and Xcr1 in mouse spleen after 90 minutes when administered at a dose of 100 μg/kg.4 For more information on Selank peptide please visit Pubmed. References & Product Citations Product Description References 1. Povarov, I.S., Kondratenko, R.V., Derevyagin, V.I., et al. Effect of Selank on spontaneous synaptic activity of rat hippocampal CA1 neurons. Bull. Exp. Biol. Med. 162(5), 640-642 (2017). 2. Kozlovskaya, M.M., Kozlovskii, I.I., Val’dman, E.A., et al. Selank and short peptides of the tuftsin family in the regulation of adaptive behavior in stress. Neurosci. Behav. Physiol. 33(9), 853-860 (2003). 3. Meshavkin, K.V., Kost, N.V., Sokolov, O.Y., et al. Naloxone-blocked depriming effect of anxiolytic selank on apomorphine-induced behavioral manifestations of hyperfunction of dopamine system. Bull. Exp. Biol. Med. 142(5), 598-600 (2006). 4. Kolomin, T., Morozova, M., Volkova, A., et al. The temporary dynamics of inflammation-related genes expression under tuftsin analog Selank action. Mol. Immunol. 58(1), 50-55 (2014).
This product is a lyophilized peptide for research use only. This product is NOT for human use and can be harmful if ingested. This product is for research/laboratory use only. This product is NOT to be injected. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and should not be misbranded, misused or mislabeled as a drug, food or cosmetic.