Monthly Archives: April 2022

YK-11 is a synthetic steroidal selective androgen receptor modulator (SARM). It is a gene-selective partial agonist of the androgen receptor (AR) and does not induce the physical interaction between the NTD/AF1 and LBD/AF2 (known as the N/C interaction), which is required for full transactivation of the AR. The drug has anabolic activity in vitro in C2C12 myoblasts and shows greater potency than dihydrotestosterone (DHT) in this regard. It has been investigated as a potential treatment for sepsis-induced muscle wasting in animal studies. 

This Sarm can significantly increase lean muscle mass and strength beyond training and nutrition alone. It stimulates follistatin production, a potent myostatin inhibitor. 

S-23 is an investigational selective androgen receptor modulator (SARM). Developed as a potential male hormonal contraceptive. It binds to the androgen receptor more strongly than older drugs such as Andarine, and in animal studies it showed both a good ratio of anabolic to androgenic effects, and dose-dependent suppression of spermatogenesis with spontaneous recovery after cessation of treatment. This SARM can help to increase lean muscle mass and decrease fat mass. 

Those who use SARMs and SARM-like compounds commonly follow 8 week cycles for lean muscle gain and strength enhancement then take the following 8 weeks off. From 5mg to 15mg per day, split into two parts, is the recommended dosage for S-23. For optimal results, the dose can be halved and taken once in the morning and once in the evening.

SR9009, also known as Stenabolic, is an agonist of Rev-ErbA (i.e., increases the constitutive repression of genes regulated by Rev-ErbA) with a half-maximum inhibitory concentration (IC50) = 670 nM for Rev-ErbAα and IC50 = 800 nM for Rev-ErbAβ. 

Activation of Rev-ErbA-α by SR9009 in mice increases exercise capacity by increasing mitochondria counts in skeletal muscle. This non-SARM can increase endurance. Stenabolic is not a SARM, but a REV-ERB which means it affects the metabolism 

Those who use SARMs and SARM-like compounds commonly follow 8 week cycles for lean muscle gain and strength enhancement then take the following 8 weeks off. Recommended